澳洲物理学论文代写:组蛋白修饰机制

澳洲物理学论文代写:组蛋白修饰机制

前人已经证实,祖细胞的表观遗传状态并不完全反映额外的胚胎干细胞系(Ohm et al., 2007)。这些研究表明,组蛋白修饰机制在早期胚胎谱系、体内和体外均存在差异。最初的体内研究是为了了解基因组广泛的翻译后组蛋白修饰。在研究过程中观察到,随着人类胎儿性腺的成熟,受纳组蛋白标志物H3K4me3和抑制性组蛋白标志物H3K27me3水平逐渐降低。在后期的H3K4me3和H3K27me3。同时发现胎儿生殖细胞H3K9me2水平较低。这在睾丸生殖细胞中是检测不到的。既往研究表明,H3K9me2常参与多能期的抑制(Hirabayashi, Gotoh, 2010)。在C. elegant种系中观察到组蛋白修饰和小的非编码RNA的动态调控(Tsai et al., 2010;Peterson和Laniel, 2004;Mattick和Makunin, 2006)。

澳洲物理学论文代写:组蛋白修饰机制
组蛋白修饰被发现向有丝分裂和减数分裂的生殖细胞系有差异地调节。这表明,组蛋白的修饰会随着人类生殖细胞分化和/或减数分裂的开始而发生变化(Jenuwein, and Allis, 2001)。在本研究中,H3K9ac在胎儿卵巢中的分布并不均匀。在这个特殊的结果之后,H3K9ac被认为是不可靠的。需要进一步的研究方向。既往研究表明,在精原细胞形成过程中,DNA甲基化具有独特的动态调控作用。这是在新生儿和产后测试中发现的(Spivakov, and Fisher, 2007)。这也揭示了非cg甲基化和5hmC标记在新生儿早产儿肌早衰症中的独特积累和分布。这些研究报告,有一个差异甲基化,已观察到的情况下,新生儿早泄。

澳洲物理学论文代写:组蛋白修饰机制

It has been established from the previous times that epigenetic status of the progenitor cells did not entirely reflect the extra embryonic stem cell lines (Ohm et al., 2007). These studies indicate that histone modifications mechanism is found to vary between early embryo lineages and in ex-vivo and in-vivo.Initially in vivo research was conducted to understand about the genome wide post translational histone modifications. It was observed during the research that the levels of permissive histone markers H3K4me3 and repressive histone mark H3K27me3 were progressively reduced with maturation of human fetal gonads. In the later stages the H3K4me3 and H3K27me3. It was also found athlete the fetal germ cells displayed lower level of H3K9me2. This was undetectable in testicular germ cells. Previous research has indicated that there H3K9me2 is often involved in the suppression during the times of pluripotency (Hirabayashi, and Gotoh, 2010). Dynamic regulation of the histone modification and small non coding RNA has been observed throughout C. elegant germ lines (Tsai et al., 2010; Peterson, and Laniel, 2004; Mattick and Makunin, 2006).

澳洲物理学论文代写:组蛋白修饰机制
Histone modifications are found to be regulated differentially going to the mitotic and meiotic germ lines. This indicates that the histone modifications are subject to change based on the onset of germ cells differentiation and /or meiosis in humans (Jenuwein, and Allis, 2001). In this particular research H3K9ac distribution was not equal among the fetal ovaries. Subsequent to this particular result of H3K9ac is not considered to be reliable. Further research direction is required. Previous studies show that the distinctive and dynamic regulation was observed in the DNA methylation during the spermatogonial stem cell formation. This was found in the neonatal and post natal tests (Spivakov, and Fisher, 2007). This also revealed a unique accumulation and distribution of the non-CG methylation and 5hmC marks in neonatal prospermatogonia. These studies report that there is a differential methylation that has been observed in the case of neonatal prospermatogonia.

COPYRIGHT © ADVANCED THESIS ALL RIGHTS RESERVED 高阶澳洲论文代写 | OUR SERVICES ARE TO BE USED FOR RESEARCH AND REFERENCE PURPOSES ONLY