论文代写价格:可生物降解共聚物

论文代写价格:可生物降解共聚物

本文报道了一种可生物降解的共聚物,在自然界中具有两亲性。该共聚物用于获得自组装的胶束纳米粒子。共聚物被称为聚钴铵癸二酸盐,P (MDS-co-CES) (Lee et al., 2009)。这些药物具有在药物和生物宏观分子中传递的能力。这些包括基因以及功能性质的蛋白质,无论是在同时的方式还是个别的方式,在几种细胞类型。在本文中,考虑了具有阳离子胶束性质的纳米粒子。它们被用来作为一种载体,用于联合递送紫杉醇和赫赛汀。这是为了在人类的表皮上实现对受体2生长因子的靶向传递(Lee et al., 2009)。这是通过协同性质的活动来抑制细胞的毒性。含有紫杉醇的纳米颗粒的大小一般小于120纳米,大约有60毫伏的zeta的潜力。在纳米粒子表面上完成了赫赛汀的肤色。在具有200纳米尺寸的生理模拟条件下,纳米粒子药物加载并发症继续得到稳定。赫赛汀是由纳米粒子以有效的方式传递的,而不是生物反应器。

论文代写价格:可生物降解共聚物
这是一种含有脂质碱的蛋白质载体。纳米粒子与赫赛汀对抗癌效果的评价很高。每天的治疗重复两次,其中Herceptin的元素对高细胞毒性有显著的影响,尤其是在乳腺癌细胞中,与任何单独的治疗相比(Lee et al., 2009)。在人类乳腺癌的癌细胞中,对这种联合传递系统的抗癌作用进行了深入的研究。这是与Her2的几种表达水平一致的。这些包括BT474、T47D和MCF7。赫赛汀的协同传递增强了紫杉醇的细胞毒性,这种增强被描述为依赖于HER2的表达水平。在本文中,这一联合交付系统的目标能力是由共焦性的图像显示的。这显著地描述了较高的细胞自然摄取(Lee et al., 2009)。这是在HER2的BT474过表达细胞中,与HEK293阴性的HER3阴性细胞相比。这种联合分娩系统可能对乳腺癌的过度表达的癌细胞有重要的临床意义。

论文代写价格:可生物降解共聚物

The article reports the use of a copolymer which is biodegradable as well as amphiphilic in nature. The co-polymer is used to obtain self-assembled micellar nano-particles. The co-polymer is termed as poly co ammonium bromide sebacate, P (MDS-co-CES) (Lee et al., 2009). These had the ability of delivering in the drugs as well as bio-macro molecules. These included genes as well as proteins of functional nature either in simultaneous manner or individual manner within several cell types. Within this article, such nano-particles were taken into consideration which had cationic micellar nature. These were used as a medium to carry for co-delivering paclitaxel as well as Herceptin. This was done to achieve paclitaxel targeted delivery for receptor 2 growth factor in the epidermis of humans (Lee et al., 2009). This was done to suppress toxicity of the cells by activities of synergistic nature. Nanoparticles loaded with Paclitaxel have a size of average nature lesser than 120 nm and there is a potential of zeta for about 60 mV. Complexion of Herceptin was done over the nano-particles surface. The nano-particle drug loading complication continued to have stability under conditions of physiological simulation with 200 nm sizes. Herceptin was delivered by nano-particles in an efficient manner than the bioPorter.

论文代写价格:可生物降解共聚物
This is a protein carrier with lipid base available commercially. The nano-particles with Herceptin depicted an effectiveness of anti-cancer highly. Daily treatment was repeated twice with the element of Herceptin depicting high cell toxicity significantly and particularly within over expressed cancer cells in breast in comparison to any individual treatment (Lee et al., 2009). Effects of anti-cancer coming from such a co-delivery system were thoroughly investigated within the cancer cells of human breast. This was done in alignment with several ranges of expression level of Her2. These were inclusive of BT474, T47D and MCF7. The Herceptin co-delivery enhanced the paclitaxel cytotoxicity and such enhancement depicted to be dependent over the expression levels of HER2. This co-delivery systems targeted ability, within the article, was shown by images of confocal nature. This depicted a higher uptake of cellular nature significantly (Lee et al., 2009). This was taken up within the BT474 overexpressed cells of HER2 in comparison to the negative HER3 negative cells of HEK293. This system of co-delivery might have essential implications clinically against the overexpressed cancer cells in the breast.

 

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